Global Healthcare

Bringing Vascular Health into Focus

One Mammogram at a Time

cmAngio® is an ANVISA registered medical device using Artificial Intelligence (AI) to detect Breast Arterial Calcifications (BAC), an incidental finding in routine screening mammograms, indicative of arteriosclerosis.

BAC are calcifications in the breast arteries that can indicate arteriosclerosis, a type of arterial stiffening that can be attributable to cardio-vascular disease. cmAngio analyzes both full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) screening mammograms to identify and mark these anomalies, which are currently only identified as incidental findings.

Importantly, cmAngio allows radiologists to use existing screening mammograms to identify women who have BAC and, when appropriate, refer them for further evaluation tied to important health outcomes without any additional radiation or procedure. It highlights the BAC directly on the image so radiologists can easily review and report.

The call to action is clear: by integrating BAC detection and localization into routine imaging, we can address one of the most pressing, under-recognized risks in women's health.

Understanding Breast Arterial Calcifications

Breast Arterial Calcifications (BAC) are deposits that form within the medial layer of breast arterial walls — a pattern of vascular mineralization known as Mönckeberg's arteriosclerosis. Unlike intimal calcifications of atherosclerosis, which narrow the arterial lumen and restrict blood flow, BAC preserve luminal patency. Yet their presence signals something clinically important: systemic vascular disease.

BAC are detected in 12–25% of women undergoing screening mammography, yet fewer than 5% of cases are formally reported1 — leaving a significant cardiovascular risk signal unacknowledged.

Research increasingly links BAC to major adverse cardiovascular events (MACE), including heart attack, stroke, heart failure, and cardiovascular mortality. BAC have also been independently associated with chronic kidney disease (CKD), type 2 diabetes, hypertension, and peripheral arterial disease — conditions that share the same underlying biology of medial vascular calcification.

Clinical diagram comparing Intimal Calcification versus Medial Calcification

Heart disease is the #1 killer of women.

Most never see it coming.

Nearly 80%4 of cardiovascular disease is preventable. Yet the majority of women aren't screened to identify potential risks — such as the presence of breast arterial calcifications.

CureMetrix changes this through contextualized precision screenings.

Heart disease diagnosis imbalance in women

69%

Women who die from heart disease and are asymptomatic or have symptoms that are missed2

5x

More women die from Heart Disease than from Breast Cancer3

<5%

Of breast arterial calcifications reported by radiologists6

Breast Arterial Calcifications impact women's health

51%

Increase in risk of heart disease or stroke5

14x

Increase in cardiovascular event-specific death5

26%

Women aged 60-79 have arterial calcification6

cmAngio Key Features

Built for clinical workflows with flexibility, security, and ease of integration.

Adjustable Operating Point

Adjustable operating point to meet clinical goals and workflow preferences.

FFDM & DBT Processing

Processes both Full Field Digital Mammography (FFDM) and Digital Breast Tomosynthesis (DBT) For Presentation exams from GE and Hologic.

Easy Integration

cmAngio easily ties into existing radiology tools and clinical workflow.

Automated Processing

BAC segments are automatically localized, marked and displayed on scorecard for review.

Batch Read Ready

Results are returned in minutes and can be read in seconds. Cleared on screening mammograms for women aged 40-90.

All Densities

Demonstrated performance across all breast densities.

BAC Detection and Localization Starts Here

See how cmAngio can unlock BAC insights from existing mammography workflows, empowering care teams with actionable detection data.

Schedule a Demo

Sources

  1. 1Loberant, Norman et al. "Prevalence and Degree of Breast Arterial Calcifications on Mammography: A Cross-sectional Analysis." Journal of Clinical Imaging Science, vol. 3, 27 Sep. 2013. doi:10.4103/2156-7514.11901
  2. 2CDC — Women and Heart Disease. www.cdc.gov/heart-disease/about/women-and-heart-disease.html
  3. 3Go Red for Women / American Heart Association — Facts. www.goredforwomen.org/en/about-heart-disease-in-women/facts
  4. 4World Health Organization / JAMA Network Open — CVD Prevention Insights. Targeted Oncology
  5. 5Nerlekar N et al. "Automated Breast Arterial Calcification Score Is Associated With Cardiovascular Outcomes and Mortality." JACC: Advances. 2024;3(11):101283. doi:10.1016/j.jacadv.2024.101283
  6. 6Allen TS, Bui QM, et al. "Automated Breast Arterial Calcification Score Is Associated With Cardiovascular Outcomes and Mortality." JACC: Advances. 2024;3(11):101283. doi:10.1016/j.jacadv.2024.101283

Disclaimer: cmAngio is FDA-cleared for commercial use for BAC detection and localization. Content and publications on this page have not been cleared by the FDA.

ANVISA

Registered in Brazil

MDSAP

Certified

ISO 13485

Certified

Global regulatory in progress. Cleared in Brazil. Targets: Canada, Australia, EU, and other key markets.